IndraLab

Statements

VEGFA binds CXCR4. 6 / 6
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"Proagniogenic miRNAs include, for example, miR494 targeting PTEN (phosphatase and tensin homolog deleted on chromosome ten) in lung cancer [ xref ] or miR -155 targeting VHL (Von Hippel–Lindau tumor suppressor) in breast cancer [ xref ], in turn, miR622 has an anti-angiogenic effect through by suppressing the CXCR4-VEGFA axis in colorectal cancer [ xref ]."
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"We demonstrate here that the expression of CXCR4 in BC cells is associated with increased expression of VEGF-A. Increased expression of VEGF and its receptors correlates with increased MVD, cell proliferation, and tumor growth rate, which impairs patient survival in diverse cancers [ xref , xref , xref ]."
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"Specifically, VEGFA, CXCR4, GLUT1, HK2, and PFKFB3 were all associated with gained enhancers."
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"Among miRNAs, miR-622 is an miRNA involved in various cancers, such as ovarian cancer, liver cancer, and gastric cancer [ xref – xref ], and it has been recently reported to regulate the angiogenesis of CRC by inhibiting CXCR4-VEGFA [ xref ]."
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"The expression of CXCR4 in BC cells was associated with increased expression of VEGF-A (Figure xref ), vimentin and p-GSK-3β and decreased expression of E cadherin (Figure xref )."
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"To determine the effect of VEGFa‐CXCR4 codelivery on differentiation of EPCs in vitro, 5 × 10 5 EPCs transfected with SPION/PEG‐PEI/plasmid (C‐V, CXCR4, VEGFa and Vector) were induced to differentiate after 14 d of induction."
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