IndraLab

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USP8 activates Carcinogenesis. 18 / 18
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"Present findings support that USP8 gene expression levels may contribute to pitutary tumorigenesis and hormonogenesis.."
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"Heterozygous Deletion of Usp8 in IECs Suppresses Tumorigenesis in Mice.."
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"Deubiquitinase USP8 increases ID1 stability and promotes esophageal squamous cell carcinoma tumorigenesis."
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"Usp8 ;Vil-Cre mice developed fewer and smaller tumors in the colon than Usp8 mice, indicating that Usp8 deficiency in IECs inhibits the colorectal tumorigenesis and tumor progression (Fig. 2 B–D)."
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"USP8 promotes the tumorigenesis of intrahepatic cholangiocarcinoma via stabilizing OGT."
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"Additionally, Usp8 inhibition combined with SAS treatment also significantly suppressed the primary lung cancer tumorigenesis and development in the KP mouse model (SI Appendix, Fig. S5 O–S)."
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"We further demonstrate USP8 promotes tumorigenesis and impacts on the sensitivity of iCCA to pemigatinib."
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"USP8 positively regulates hepatocellular carcinoma tumorigenesis and confers ferroptosis resistance through beta-catenin stabilization."
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"Taken together, our results suggest that deletion of Usp8 significantly inhibits colorectal and lung tumorigenesis and tumor progression accompanied by increased lipid peroxidation in tumors."
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"Intriguingly, GLI1 is the downstream target of sonic hedgehog (SHH) signaling that is deregulated in corticotroph tumors [57] indicating that both USP8 and USP48 might trigger corticotroph tumorigenesis via the same pathway."
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"Several targets, including HER-2, TRAF6, and Akt, are implicated in USP8-mediated tumorigenesis [31–33]."
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"Ectopic expression of USP8 promotes ESCC tumorigenesis by suppressing ID1 degradation, whereas knockdown of USP8 results in the opposite phenotypes in vitro and in vivo."
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"Moreover , we found that TXNIP is a novel downstream target of ID1 , and USP8 promotes ESCC tumorigenesis by activating the ID1-TXNIP pathway ."
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"The data of Kasahara et al. [88] also point to a reciprocal relationship between primary cilia and cell proliferation which may provide further insights into mechanisms of tumorigenesis caused by dysregulated USP8."
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"These observations suggest that the USP8 and NOTCH2 variants identified in IECs may enhance protein function and promote tumorigenesis."
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"Heterozygous deletion of Usp8 impedes colon tumorigenesis and tumor progression in a murine colorectal cancer model."
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"USP8 positively regulates hepatocellular carcinoma tumorigenesis and confers ferroptosis resistance through β-catenin stabilization [11]."
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"Moreover, we found that TXNIP is a novel downstream target of ID1, and USP8 promotes ESCC tumorigenesis by activating the ID1-TXNIP pathway."
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