IndraLab

Statements

USP13 activates MITF. 4 / 5
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"USP13 promotes melanoma cell invasion by stabilizing the microphthalmia-associated transcription factor."
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"On the other hand, overexpression of the deubiquitinase USP13, which has been identified as a key regulator of MITF turnover, can enhance the basal half-life of the MITF protein to up to 4h (Zhao etal., 2011)."
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"More recently, it was shown that MITF is targeted by the de-ubiquitinase USP13, a theoretically drug-able protease whose suppression results in strong downregulation of MITF protein levels."
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"Consequently, ectopic expression of USP13 stabilized MITF and up-regulated MITF target genes, whereas USP13 knockdown decreased MITF protein, but not mRNA, and blocked melanoma cell proliferation.A range of additional phosphorylation events have been detected in various high-throughput proteomic screens (PhosphSitePlus, http://www.phosphosite.org/proteinAction?id=1001&showAllSites=true); however, the significance of these modifications is yet to be determined."
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