IndraLab

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USP28 deubiquitinates SNAI1. 5 / 5
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"Subsequently, USP28 interacted with and deubiquitinated Snail1; these effects were dependent on GSK-3beta-mediated phosphorylation."
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"Moreover, USP28 mediated the Pard3 silencing-induced deubiquitination and stabilization of Snail1, thereby promoting BC migration and invasion."
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"As expected, ectopic expression of wild-type USP28 reduced the polyubiquitination of Snail1 in a dose dependent manner (Fig. 5E)."
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"As Fig. 5F shown, wild-type USP28 instead of the DUB dead mutant USP28C 1A reduced the polyubiquitination of Snail1, whereas USP28 silencing increased Snail1 polyubiquitination."
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"The results above suggest that USP28 may stimulate EMT via its deubiquitination of LSD1 and Snail and then suppress EMT-related molecules.In addition to the molecules involved in EMT, other molecules, such as Lin28A, which is a crucial regulator of invasiveness, can also accelerate metastasis [84]."
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