IndraLab

Statements

Rhein inhibits NLRP3. 14 / 14
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"Furthermore, rhein can inhibit NF-κB and NALP3 inflammatory pathways, thereby attenuating inflammatory responses (Ge et al., 2017)."
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"Emodin and rhein inhibited the cascade reaction of NALP3 inflammasome, reduced the related inflammatory cytokines and alleviated tissue damage ( Han JW et al., 2015 ; Ge H et al., 2017 )."
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"In addition, inflammasome pathways NF-κB and NLRP3 are inhibited by rhein, contributing to its anti-inflammatory action."
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"Furthermore, DIA metabolite, rhein, was shown to inhibit NALP3 inflammasome pathways via suppressing caspase-1 activity and IL-1β production [21] ."
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"Similarily, rhein from R. palmatum was demonstrated to inhibit caspase-1 protease activity and NLRP3 assembling [ 24 ]."
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"Overall, rhein, diacerein, emodin, aloe emodin, and 1,8-dihydroxyanthraquinone inhibited the NLRP3 transcription independent of TLR4 signaling pathway.The direct role of rhein, diacerein, emodin, aloe emodin, and 1,8-dihydroxyanthraquinone in regulating the assembly of NLRP3 inflammasome was explored by changing cell culture medium with LPS before the treatment of these abovementioned anthraquinones and the stimulation of nigericin."
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"RFAs including rhein/diacerein, emodin, aloe emodin and 1,8-dihydroxyanthraquinone inhibited NLRP3 inflammasome by inhibiting IL-1β (Fig. 1C), the cleavage of pro-caspase-1(Fig. 1E) and the formation of ASC specks (Fig. 1F, G) in mouse BMDMs stimulated by LPS + nigericin, but bad no effect on TNF-α (Fig. 1D)."
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"RFAs including rhein/diacerein, emodin, aloe emodin and 1,8-dihydroxyanthraquinone inhibited NLRP3 inflammasome by inhibiting IL-1β, but had no effect on TNF-α."
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"Surprisingly, the inclusion of rhein in FG enhanced the therapeutic effect, promoted ECM metabolism of NPCs to a greater extent, enhanced the anti-inflammatory effect of rhein, inhibited NLRP3 aggregation, and thus prevented the occurrence of cell pyroptosis."
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"In contrast, rhein pretreatment significantly abrogated the increased NLRP3 and cleaved caspase-1 expression."
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"In addition, researchers found that rhein could prevent the activation of the Nox2 redox-mediated NLRP3 inflammasome and modulate the Nrf2-dependent redox balance to block the maturation and secretion of IL-1β in macrophages, one of the key pro-inflammatory cytokines (108)."
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"Rhein, DIA metabolite, similarly inhibited NALP3 inflammasome pathways via suppressing caspase-1 activity and IL-1β production [21] ."
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"In a third study, Rhein, a traditional Chinese medicine (lipophilic anthraquinone) found in medicinal herbs that has antiviral activities, inhibited RSV-induced activation of the NLRP3 inflammasome and production of lung IL-33 in mice [115]."
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"RFAs including rhein/diacerein, emodin, aloe emodin and 1,8-dihydroxyanthraquinone inhibited NLRP3 inflammasome."
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