IndraLab

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Hydroxychloroquine inhibits CASP1. 5 / 5
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"Finally, we show that treatment of RC/RC mice with the anti-inflammatory drug HCQ, which can inhibit the NLRP3/Caspase-1 inflammasome among its effects, both protects kidney function in females and restrains cystic growth in both females and males, suggesting its potential use in the treatment of ADPKD patients.In initial studies we found that the expression of multiple cellular sensors that act upstream of Caspase-1/inflammasome activation are elevated in cystic kidneys of both human ADPKD and PKD model mice, suggesting that the inflammasome priming process has occurred."
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"Apart from inhibiting NLRP3 activator initiation signal, HCQ also prevents the activation of caspase-1 in vitro [32,33,34,35,36]."
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"Caspase 1 activation was also inhibited by HCQ in a dose dependent manner."
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"Again, HCQ could not inhibit IL-1beta nor caspase 1 activation triggered by nigericin."
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"In vitro, HCQ inhibited IL-1beta and caspase 1 activation induced by ATP in a dose dependent manner."
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