IndraLab

Statements

ATXN3 activates calcium(2+). 2 / 2
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"Different ataxin-3 amyloid aggregates induce intracellular Ca (2+) deregulation by different mechanisms in cerebellar granule cells."
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"However, only the pre-fibrillar aggregates of expanded ATX3 (the only variant which forms bundles of mature fibrils) triggered a characteristic Ca (2+) response at a later stage that correlated with a larger hydrophobic exposure relative to the two other variants."
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