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IL6 increases the amount of USP18. 7 / 8
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"We could also observe an increase at the protein level of the inflammatory genes Serpine1, USP18 and IL1-b cytokine, activated by the inflammasome response (Fig. 2b), and an accumulation of the secreted cytokine IL6 (Fig. 2c)."
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"Treatment of Huh7.5 cells and primary murine hepatocytes with LPS and TNF-alpha, but not IL-6 or IL-10, led to upregulated USP18 expression and induced an IFN-alpha refractory state, which was reversed by USP18 knockdown."
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"In the present study, treatment of hepatic cells with LPS and TNF-α, but not IL-6 or IL-10, led to upregulated USP18 expression in hepatocytes."
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"In the present study, treatment of hepatic cells with LPS and TNF-alpha, but not IL-6 or IL-10, led to upregulated USP18 expression in hepatocytes."
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"USP18 mRNA expression was induced by TNF-α and LPS but not by IL-6 or IL-10 (Fig. 1A)."
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"Treatment of Huh7.5 cells and primary murine hepatocytes with LPS and TNF-α, but not IL-6 or IL-10, led to upregulated USP18 expression and induced an IFN-α refractory state, which was reversed by USP18 knockdown."
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"USP18 mRNA expression was induced by TNF-alpha and LPS but not by IL-6 or IL-10 (XREF_FIG)."
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