IndraLab

Statements

SCN2A inhibits PRNP. 3 / 3
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reach
"We now demonstrate that exposure of ScN2a cells to 3 microg of PPI generation 4.0/ml for 4 weeks not only reduced PrP (Sc) to a level undetectable by Western blot but also eradicated prion infectivity as determined by a bioassay in mice."
11238871
reach
"Chronic exposure of ScN2a cells to low noncytotoxic concentrations of branched polyamines for 1 wk reduced PrP (Sc) to an undetectable level, a condition that persisted at least 3 wk after removal of the compound."
10588739
reach
"Similarly, CpV extract also resulted in the inhibition of aggregation of misfolded rPrP generated by PrP seed-mediated conversion in RT-QuIC, Furthermore, our ScN2a cell-based assay results clearly demonstrate that CpV extract suppresses PK-resistant PrP propagation, while a complete elimination of PrP from the cells was impossible within the non-cytotoxic concentration range."
36613636