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"In conclusion, these findings suggest that chronic alcohol consumption down-regulates STAT2 and PKR, but up-regulates p42/44 mitogen activated protein kinase (p42/44MAP kinase), which may cause down-regulation of IFN-alpha signaling in the liver of ALD patients."

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"Alcohol consumption has also been reported to activate STAT1/3 [20–22] but inhibited STAT2 [22]."