IndraLab

Statements

USP7 bound to CTNNB1 activates signal transduction. 3 / 3
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"Notably, USP7 can directly bind with beta-catenin to activate the Wnt and beta-catenin signalling pathway and induce epithelial-mesenchymal transition (EMT) of OS cells."
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"Zeng et al. found that USP7 was significantly upregulated in osteosarcoma and could directly bind to β-catenin and activate the Wnt/β-catenin signaling pathway in order to induce epithelial-mesenchymal transition (EMT) (103)."
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"Wnt/β-catenin signaling pathway: USP7 can directly bind to β-catenin, activating the Wnt/β-catenin signaling pathway and inducing epithelial–mesenchymal transition (EMT), a crucial process in tumor cell invasion and metastasis [36]."
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