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USP13 ubiquitinates PTEN. 5 / 5
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"In order to determine whether PTEN is a direct substrate of USP13, we purified USP13 and ubiquitinated PTEN and then incubated them in a cell-free system."
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"For example, USP13 prevents tumor cell growth by deubiquitinating PTEN in breast cancer, OSCC and bladder cancer."
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"Ubiquitin C-terminal hydrolase 13 (USP13) has been found to reverse PTEN ubiquitination thus leading to its stabilization in breast cancer cells [ 92 ]."
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"Furthermore, several DUBs, including HAUSP/USP7, USP10, USP11, USP13, OTUD3, and Ataxin-3 have been shown to reverse the ubiquitination of PTEN, a key antagonist in the PI3K growth-promoting pathway, implicating its function in cancer-specific contexts [15]."
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"USP13, another PTEN deubiquitinase, different with USP7-mediated deubiquitination of PTEN monoubiquitination, it reverses PTEN polyubiquitination, thus promoting the PTEN stabilization and tumor suppr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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