IndraLab

Statements

SKP2 activates USP18. 5 / 6
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"These patients were deficient in ISG15, leading to increased S-phase kinase-associated protein 2 (SKP2) mediated proteolysis of USP18 and subsequently an upregulated IFN gene signature [80] ."
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"As summarized above, SKP2 can target USP18 for degradation, while ISG15 has an opposite action, being required for accumulation of USP18 as seen in IFN stimulated cells."
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"Patient fibroblasts, transduced with control luciferase (Luc) or with USP18, were treated with IFNalpha and SKP2 was immunoprecipitated."
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"SKP2 (S-phase kinase associated protein 2) was found to target USP18 to ubiquitination and proteosomal degradation 10."
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"However, the noncovalent binding of free intracellular ISG15 with USP18 inhibits SKP2-mediated USP18 degradation [75,77]."
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