IndraLab

Statements

RBM25 activates SCN5A. 5 / 5
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"RBM25 and LUC7L3complex mediates abnormal SCN5A mRNA regulation."
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"LUC7L3 and RBM25 were elevated in human HF tissue and mediated abnormal SCN5A splicing regulation in the two cell types tested."
21859973
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"The splicing factors RBM25 and LUC7L3 are elevated in human heart failure tissue and mediate truncation of SCN5A mRNA in both Jurkat cells and human embryonic stem cell derived cardiomyocytes [XREF_BIBR]."
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"Finally, while experimental manipulations of RBM25 and LUC7L3 were sufficient to cause or prevent SCN5A mRNA dysregulation, it remains possible that some of the other splicing factors increased in HF contribute to abnormal SCN5A splicing."
21859973
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"Two of these splicing factors, RBM25 and LUC7L3, were elevated in human heart failure tissue and mediated truncation of SCN5A mRNA in both Jurkat cells and human embryonic stem cell derived cardiomyocytes."
21859973