IndraLab

Statements

OTUD7B activates Stomach Neoplasms. 5 / 5
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"OTUD7B is a novel DUB of the YAP1 pathway and accelerates GC progression ."
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"Moreover, OTUD7B overexpression promoted GC cell proliferation and metastasis both in vitro and in vivo, whereas OTUD7B knockdown exhibited opposing biological effects."
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"In vitro assays revealed that genetic knockout of OTUD7B markedly reduced the migration and invasion of GC cells, while overexpression of OTUD7B led to enhanced cellular migration and invasion."
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"OTUD7B is a novel DUB of the YAP1 pathway and accelerates GC progression."
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"Mechanistically, OTUD7B likely promotes GC metastasis through the WNT signaling pathway, specifically targeting β-catenin."
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