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OTUD3 inhibits RIGI. 6 / 6
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"These results suggest that OTUD3 deubiquitinates K63-linked polyubiquitination of RIG-I and MDA5.Overexpression of OTUD3 in HEK293T cells inhibited the oligomerization of RIG-I or MDA5 when these were[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Coinciding with these observations, the overexpression of OTUD3 markedly inhibited the self-association of RIG-I and MDA5, as well as the association of MAVS with RIG-I or MDA5 ( Figures S4 E–S4H)."
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"Taken together, these data suggest that OTUD3 inhibits RNF135-induced RIG-I and TRIM65-induced MDA5 activation."
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"In contrast, knockdown OTUD3 in HEK293T by CRISPR-Cas9 cells enhanced the self-association of RIG-I and MDA5, and the association of MAVS with RIG-I or RIG-I or MDA5 ( Figures S4 I–S4L)."
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"In vitro pull-down experiments showed that overexpression of OTUD3 inhibited the binding of RIG-I to 5′-ppp-dsRNA ( Figure S4 M), as well as of MDA5 to poly(I:C)-HMW ( Figure S4 N)."
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"These findings suggest that OTUD3 inhibits the oligomerization of RIG-I and MDA5 and prevents the binding of viral RNA to RIG-I and MDA5.To determine the functional role of OTUD3 in the activation of [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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