IndraLab

Statements

USP22 activates cell differentiation. 7 / 7
| 7
reach
"Research has shown that USP22 can enhance myeloid differentiation in Kras mice by stabilizing the PU.1 protein and decreasing the risk of AML [14]."
39048945
reach
"On the contrary, Usp22 overexpression leads to increased differentiation of ESCs into EBs even in the absence of stimuli that drives differentiation [XREF_BIBR]."
27057639
reach
"USP22 deficiency in Ras-driven myeloproliferative neoplasm blocks myeloid differentiation promoting acute myeloid leukemia (37)."
38382674
reach
"Knockdown of Usp22 shortened the half-life of Hes1, delayed its oscillation, and enhanced neuronal differentiation in mouse developing brain, whereas mis expression of Usp27x reduced neuronal differentiation."
25846153
reach
"In addition, Sussman RT, et al. have reported that USP22 promotes embryonic stem cell differentiation through transcriptional repression of Sex determining region Y-box 2 (Sox2) XREF_BIBR."
24466336
reach
"USP22 modulated embryonic stem cell differentiation through acting as a transcription repressor of SOX2 , which contributes to the transition from self-renewal to differentiation in embryonic stem cel[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36371028
reach
"Additionally, the oncogenic PML-RARα fusion protein is also stabilized in an USP22- and K394-mediated manner, through which USP22 defines sensitivity towards ATRA-mediated APL differentiation."
38467608