IndraLab

Statements


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"45 Only topical doxepin, a tricyclic antidepressant and potent H1 and H2 antagonist, has been shown to significantly reduce pruritus in patients with AD, lichen simplex chronicus, contact dermatitis and nummular dermatitis."

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"The change in itch intensity (VAS) was not different during the doxepin and placebo period (p = 0.994); neither the doxepin cream nor placebo cream reduced itch intensity."

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"Only topical doxepin was shown to provide some relief (2 ~ 3 hours duration), but did not effectively relieve nightly bouts of itch."

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"In addition, creams containing local anesthetics [XREF_BIBR], capsaicin, doxepin [XREF_BIBR], strontium nitrate [XREF_BIBR], or nedocromil sodium [XREF_BIBR] can be helpful to relieve itch."