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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

COPS5 activates proteolysis. 2 / 4

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"Moreover, the paramyosin accumulations of unc-96 and unc-98 mutants contain CSN-5, a highly conserved component of the COP9 signalosome, which is implicated in regulating ubiquitin mediated proteolysis and is located at A-bands."

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"Loss of a CSN subunit, especially CSN5 and CsnE with its catalytic deneddylase activity, leads to mis regulation of CRLs and to a disturbed protein degradation."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...