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COPS5 activates proteolysis. 3 / 5
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"The Jab1/COPS5-related genes screened in GEPIA2 and STRING were subjected to GO and KEGG enrichment analysis, and KEGG results showed that Jab1/COPS5-related genes were enriched in ubiquitin mediated proteolysis and cell cycle (Figure 7E)."
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"Moreover, the paramyosin accumulations of unc-96 and unc-98 mutants contain CSN-5, a highly conserved component of the COP9 signalosome, which is implicated in regulating ubiquitin mediated proteolysis and is located at A-bands."
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"Loss of a CSN subunit, especially CSN5 and CsnE with its catalytic deneddylase activity, leads to mis regulation of CRLs and to a disturbed protein degradation."
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