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EMMAA Bob with Bioagents

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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

COPS5 activates AR. 4 / 4

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"Inhibition of CSN5 inhibited its oncogenic function by targeting AR signaling, DNA repair, multiple oncogenic pathways, and spliceosome regulation."

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"Consistent with knockdown of CSN5, CSN5i-3 suppressed AR signaling through directly inhibiting both AR and AR-V7 proteins (Figs."

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"Knockdown of CSN5 directly reduced AR expression , including the AR-V7 and AR signaling pathways ( Figs ."

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"Our data indicated that CSN5 not only directly regulated AR expression but also collaborated with AR partner TFs to modulate AR signaling ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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