IndraLab

Statements

COPS5 activates AR. 4 / 4
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eidos
"Our data indicated that CSN5 not only directly regulated AR expression but also collaborated with AR partner TFs to modulate AR signaling ."
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eidos
"Knockdown of CSN5 directly reduced AR expression , including the AR-V7 and AR signaling pathways ( Figs ."
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"Consistent with knockdown of CSN5, CSN5i-3 suppressed AR signaling through directly inhibiting both AR and AR-V7 proteins (Figs."
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"Inhibition of CSN5 inhibited its oncogenic function by targeting AR signaling, DNA repair, multiple oncogenic pathways, and spliceosome regulation."
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