IndraLab

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Notch decreases the amount of SCN5A. 4 / 4
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"We previously reported that Notch activation within the RA leads to persistently reduced Scn5a expression, CV slowing, and reduced dV /dt consistent with reduced sodium current, without affecting the resting membrane potential (RMP) or APD (39)."
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"Utilizing a genetic mouse model to transiently activate Notch signaling within adult atrial myocardium we found that, in contrast to its effects on ventricular myocardium, transient Notch activation in atrial myocardium reduces Scn5a expression, which encodes the major sodium channel in the heart."
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"Notch induction reduces Scn5a expression in the right atrial myocardium, and since mutations within Scn5a have been linked to familial SSS, this is a plausible mechanism for heart rate slowing after transient Notch activation [XREF_BIBR]."
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"It was discovered that a transient Notch pulse could down-regulate SCN5A expression, which might result in a slowed atrial conduction velocity (Qiao et al., 2017)."
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