IndraLab

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TGFB activates USP44. 4 / 4
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"Suspecting that USP44 may be up-regulated in T cells by TGF-beta, we examined the promoter of the mouse and human USP44 gene using R-vista analysis software."
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"During iTreg differentiation, TGF-beta signaling induces USP44 upregulation."
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"Notably , TGF-beta induces USP44 expression during iTreg differentiation ."
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"Interestingly, ablating TGF-beta signaling in this system with an antibody neutralizing the cytokine reduced USP44 expression in cells stimulated with PMA and Iono without exogenous TGF-beta (Fig XREF_FIG C), suggesting that induced USP44 activity may be augmented by trace amounts of TGF-beta in the serum complemented culture media (RPMI) used in these experiments."
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