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USP15 activates Neoplasm Invasiveness. 45 / 45
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"USP15 knockdown significantly inhibited cell proliferation, invasion and epithelial-mesenchymal transition (EMT) of GC in vitro, while overexpression of USP15 promoted these processes."
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"Herein, we found that USP-15 enhanced the cell stemness, migration, invasion, and EMT of CRC cells, and USP-15 knockdown led to the opposite results ( Figs."
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"On the other hand, SRSF1 is upregulated by high USP15 and USP4 that enhance cell proliferation and invasion (Fig. 7D)."
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"Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2) serves as a lysyl hydroxylase, which has been found to interact with USP15, which promotes CRC invasion and metastasis via activating the AKT/mTOR pathway [120] (Figure 6)."
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"USP15 promotes cell proliferation, invasion and EMT progression of GC via regulating the Wnt/beta-catenin pathway, which suggests that USP15 is a novel potential therapeutic target for GC."
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"USP15 promoted cell proliferation, invasion, and epithelial-mesenchymal transition of GC cells in vitro and tumor growth in vivo."
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"USP15 promoted cell proliferation, invasion, and epithelial-mesenchymal transition (EMT) of GC cells in vitro and tumor growth in vivo."
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"Knockdown of USP15 inhibits cell proliferation, invasion, and EMT progression of GC in vitro."
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"As shown in Figure 2D and Figure 2E, USP15 silencing suppressed GC cell migration and invasion."
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"USP15 overexpression promotes cell proliferation, invasion, and EMT progression in GC."
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"USP15 depletion significantly decreased PTC cell proliferation, migration, and invasion."
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"Overexpression of USP15 promoted GC cell migration and invasion, while USP15-C269S did not (Figure 3D and E)."
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"The overexpression of USP15 promoted the capacity of proliferation, migration, and invasion in ccRCC CAKI1 and 769-P cells, and these malignant biological properties were diminished by USP15 deletion in 786-O cells."
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"Collectively, these data demonstrated that USP15 overexpression promoted GC proliferation, invasion, and EMT progression."
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"In this study, IHC analyses showed that the high expression of USP15 was closely related to the depth of invasion, LNI, TNM stage, which indicated that USP15 acted as an oncogene, thereby promoting GC invasion, metastasis, and progression."
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"Furthermore, we found that USP15 promotes cell proliferation, migration, and invasion through HMGB1."
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"Since MMP-mediated degradation of the basement membrane is a pivotal process for tumor metastasis [ 28 , 29 ], we determined whether MMPs can regulate USP15-mediated NSCLC cell proliferation and invas[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Subsequently, we further found that USP15 can significantly promote the migration and invasion of GC cells in vitro."
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"USP15 knockdown significantly inhibited cell proliferation , invasion and epithelial-mesenchymal transition ( EMT ) of GC in vitro , while overexpression of USP15 promoted these processes ."
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"Strikingly, attenuation of USP15 expression greatly attenuated the proliferation, migration, and invasion of bladder cancer cells."
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"In addition to promoting proliferation, migration, and invasion of ccRCC cells, USP15 accelerated tumor in situ growth and lung metastasis in experimental animals."
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"The above findings indicated that USP15 may promote cell proliferation, migration, invasion and EMT process to become an oncogene of GC."
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"USP15 promotes cell proliferation , invasion and EMT progression of GC via regulating the Wnt / beta-catenin pathway , which suggests that USP15 is a novel potential therapeutic target for GC ."
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"Furthermore, USP15 promoted cell proliferation, invasion, and EMT progression via the Wnt/β-catenin signaling pathway in vitro and promoted the growth of GC cells in vivo."
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"USP15 can promote the multiplication, migration and invasion of bladder carcinoma cells in vitro."
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"USP15 enhances autophagy via the TRAF6-BECN1 axis, promoting lung cancer migration and invasion (9)."
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"Furthermore, the knockdown of USP15 could also reduce the migration and invasion capacity of PTC cells as evaluated by transwell invasion assays (Figures 5C and 5D) (PTC cell VS Ctrl, P<0.001) and wound healing (Figures 5E and 5F) (PTC cell VS Ctrl, P<0.001), whereas this phenomenon was reversed in USP15 overexpressed B-CPAP cells (Figures 5G and 5H) (PTC cell VS Vector P<0.001)."
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"USP15 can promote the proliferation and invasiveness of bladder cancer by mediating the NF-kappaB signaling pathway."
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"USP15 knockdown significantly inhibited cell proliferation, invasion and epithelial-mesenchymal transition of GC in vitro, while overexpression of USP15 promoted these processes."
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"USP15 promotes cell proliferation, invasion, and EMT progression of GC via regulating the Wnt/β-catenin pathway."
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"Collectively, these results strongly suggest that USP15 promotes the proliferation, invasion, and migration of bladder cancer cells through the NF-κB pathway."
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"USP15 knockdown significantly impeded cell proliferation, invasion, epithelial-mesenchymal transition, and distal colonization in xenograft models, while enhancing oxaliplatin's antitumor effect."
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"Conclusion:. USP15 enhances the proliferation, migration, invasion, and collagen deposition of hypertrophic scar-derived fibroblasts by deubiquitinating TbetaRI in vitro."
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"USP15 can activate NF-kappaB signaling pathway via BRCC3, thereby promoting the growth, migration and invasiveness of bladder cancer."
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"The results revealed that excessive expression of BRCC3 promoted the growth, invasion, and migration of bladder cancer cells and also counteracted the reduced proliferation and invasion caused by the inhibition of USP15 expression (Figure 7F)."
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"USP15 Promotes the Proliferation, Migration, and Invasion of Hypertrophic Scar-Derived Fibroblasts."
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"In summary, our study demonstrates that USP15 can activate the NF-κB signaling pathway through BRCC3, thus enhancing the proliferation, migration, and invasiveness of bladder cancer cells."
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"USP15 and USP4 promote cell proliferation and invasion in lung cancer cell lines."
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"Matrigel invasion assays showed that USP15 knockdown significantly inhibited the invasion of hypertrophic scar–derived fibroblasts (0.37 ± 0.03-fold; p < 0.05), whereas USP15 overexpression significantly promoted the invasion of hypertrophic scar–derived fibroblasts (2.17 ± 0.11-fold; p < 0.05)."
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"As revealed in Fig. 8 a, loss of TFAP4 repressed the USP-15 overexpression-induced promotion of cell migration and invasion."
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"USP15 promotes tumor cell invasion and proliferation in GBM [40]."
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"(Right) The invasion of hypertrophic scar fibroblasts in blank, vector, and USP15 groups was detected by Matrigel invasion assays (*p < 0.05), http://links.lww.com/PRS/E646.] These results suggest that USP15 promotes the proliferation, migration, and invasion of hypertrophic scar–derived fibroblasts."
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"As revealed in Fig. 3 a-d, USP-15 knockdown inhibited the migration and invasion abilities of CRC cells."
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"Given the observation that USP-15 promoted the migration and invasion of CRC cells in vitro, we considered whether USP-15 act as a similar role in vivo."
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"The Cell Counting Kit-8, scratch, and invasion assays showed that USP15 knockdown significantly inhibited the proliferation, migration, and invasion of the hypertrophic scar–derived fibroblasts, and USP15 overexpression showed the opposite trends."
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