IndraLab

Statements

CYLD inhibits Multiple Myeloma. 4 / 4
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"Loss of the deubiquitinating enzyme CYLD, which acts as a negative regulator of nuclear factor kappa-light-chain-enhancer of activated B cells (NFkappaB) and Wnt Signaling, increases the aggressiveness of MM [XREF_BIBR]."
33327527
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"Functional assays revealed that CYLD represses MM cell proliferation and survival."
27775078
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"Loss of the deubiquitinating enzyme CYLD has been shown to enhance MM aggressiveness via Wnt pathway activation [XREF_BIBR]."
28476164
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"Altogether, our findings identify CYLD as a negative regulator of NF-kappaB and Wnt and beta-catenin signaling in MM and indicate that loss of CYLD enhances MM aggressiveness through Wnt pathway activation."
27775078