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"For example, the gene encoding the K + channel subunit, Kcnv2, which is downregulated by cocaine, showed increased H3 dimethyl-K9 and K27 at its promoter without a change in histone acetylation, while PDYN and ARC, which are upregulated by cocaine, showed increased acetylation on their promoters without any changes in methylation (see XREF_FIG)."