IndraLab

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BAP1 deubiquitinates BARD1. 2 / 2

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"BRCA1 forms a complex with BARD1 to generate an active E3 ubiquitin ligase that can auto-ubiquitinate to promote its own destruction, while BAP1 is a DUB that by deubiquitinating BARD1 can disrupt this complex and reduce its turnover [12, 15]."

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"BAP1 also deubiquitinates BARD1 and modulates the BRCA1-BARD1 complex during DNA damage response [ 14 ]."

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INDRA sources:

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IndraLab

Statements

BAP1 deubiquitinates BARD1. 2 / 2

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