IndraLab

Statements

NFkappaB increases the amount of UCHL1. 4 / 4
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"Interestingly, overexpression of CDR1as elevates the NF-kappaB inhibited UCHL1 promoter activity and thereby increases the mRNA and protein levels of UCHL1."
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"UCHL1 was directly transcribed by NF-κB, thus forming a positive feedback signaling loop in CFs during cardiac fibrosis."
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"Activation of NF-kappaB up-regulates UCH-L1 expression following changing of other podocytes molecules, such as nephrin and snail."
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"In vitro experiments confirmed that tumor necrosis factor-alpha induced NF-kappaB activation, which led to UCH-L1 overexpression, UPS impairment, the upregulation of desmin and the downregulation of synaptopodin in A20 gene silenced podocytes."
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