IndraLab

Statements

OTUB2 inhibits glycolytic process. 5 / 5
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"Having demonstrated that OTUB2/SNX29P2 causes impaired glycolysis and increased OXPHOS in ovarian cancer cells, we then identified the mediator of this function."
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"Activation of CA9 restores OTUB2-mediated inhibition of glycolysis and tumor growth; thus, CA9 inhibitors might be a promising strategy for ovarian cancer treatment."
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"OTUB2/SNX29P2 Suppresses Glycolysis and Promotes OXPHOS in Ovarian Cancer.."
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"The results of gene set enrichment analysis (GSEA) indicated that overexpression of either OTUB2 or SNX29P2 suppresses the glycolysis pathway and enhances OXPHOS activity (Fig. 4 A and B)."
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"Overexpression of OTUB2 or SNX29P2 in ES-2 cells inhibited glycolysis and lactate production while increasing OXPHOS (Fig. 4 C–E and SI Appendix, Fig. S4 A–C)."
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