IndraLab

Statements

CXCR4 binds CXCR2 and MIF. 11 / 11
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"To identify the MDSC MIF receptor, we evaluated two known receptors that bind MIF, CXCR2 and CXCR4."
27145382
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"In addition, MIF can bind to CXCR2 and CXCR4 and lead to the proliferation of pulmonary artery smooth muscle cells and contribute to hypoxic PH xref - xref ."
24951765
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"In addition to CD74, the direct binding of MIF and CXCR2 or CXCR4 was also observed to induce calcium influx and the rapid activation of integrins by Gi-coupling [ xref ]."
25821355
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"High-affinity binding of MIF to CXCR2 and CXCR4 represents non-cognate interactions between an ACK and CKRs (Table xref ) and gives rise to leukocyte recruitment responses in inflammation and atherogenesis ( xref , xref , xref , xref )."
30729111
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"It has also been clearly demonstrated that MIF binding to its cognate receptors, CXCR2 and CXCR4, promotes leukocyte recruitment to the site of inflammation( xref , xref – xref )."
27082509
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"Next to the cognate receptor CD74-CD44, MIF can also interact with the chemokine receptors CXCR2 and CXCR4."
35464430
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"MIF may also bind to CXCR2 and CXCR4, which may be responsible for its chemotactic properties."
31497025
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"In the context of atherosclerosis, interference with MIF binding to both CXCR2 and CXCR4 by using a MIF blocking antibody interfered with MIF’s pro-atherosclerotic functions (Bernhagen et al., xref ), while it would leave the protective homeostatic functions of the CXCL12-CXCR4 axis preserved (Koenen and Weber, xref )."
23720662
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"CXCR2 and CXCR4 are functional receptors of MIF; MIF binding to CXCR2 or CXCR4 triggers calcium influx, induces a rapid activation of integrins, and can subsequently mediate integrin-dependent arrest and chemotaxis of monocytes and T cells [ xref ]."
25301842
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"Inflammatory leukocyte recruitment is dependent on MIF-CXCR2 and MIF-CXCR4 interactions [ xref ]."
19602265
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"Signaling through CD74/CD44 induces cell proliferation and inhibits apoptosis, and MIF interaction with the non-cognate receptors CXCR2 and CXCR4 modulates the migration of immune cells ( xref )."
28562118