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USP22 deubiquitinates HSPA5. 2 / 2
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"It should be noted that while upregulation of the best characterized H2Bub1 DUB, USP22, has been associated with poorer breast cancer patient outcomes [ 167 ], to date, mechanistic investigations indi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These authors also reported down regulation of the Heat shock protein family A (Hsp70) member 5 (HSPA5), an HSP70 family member involved in the unfolded protein response, in tumors from Usp22 null mice, consistent with reports that USP22 mediates deubiquitination of HSPA5 in human prostate cancer cells [15]."
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