IndraLab
Statements
KCNS3 activates potassium(1+). 2 / 2
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2
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"The water channel AQP1 and the main calcium regulated ion channel in chondrocytes TRPV4 are strongly increased in Group B. XREF_BIBR Also increased in Group B are other calcium activated potassium channels including KCNN3, 4, XREF_BIBR the voltage sensitive calcium activated chloride channel ANO1 and potassium channels KCNQ5, KCNS3 and KCTD12, KCNMB4 (XREF_TABLE)."
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"Thus, intracellular potassium imbalance, caused by improper KCNS3 regulation, might lead to cholinesterase inhibition, astrocyte toxicity, and, ultimately, motor neuron degeneration.The rs3172469 SNP is located in intron 1 of the B-cell lymphoma 6 (BCL6) gene, and encodes a transcriptional repressor that may be involved in the modulation of several metabolic pathways, the most popular being related to B cell activation implied in lymphoma pathogenesis [62]."