IndraLab

Statements

USP22 activates Neoplasm Invasiveness. 9 / 9
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"USP22 knockdown reduced the overall infiltration of late‐stage exhausted TIM‐3+ CD8 T‐cells and attenuated the upregulatory effect induced by Taz or combination therapy (Figure 6H)."
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"Furthermore, the knockdown of USP22 reduced the infiltration of M2 macrophages, but no significant differences in M2 infiltration were observed with Taz treatment or immunotherapy."
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"Similar results have been reported in liver tumors (19), where ablation of USP22 in liver tumor cells has been shown to increase tumor immunogenicity and promote T-cell infiltration into the resulting liver tumors."
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"Moreover, given that USP22 is positively correlated with M2 macrophage infiltration in public datasets, our study indeed found that knockdown of USP22 can reduce M2‐type macrophage infiltration."
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"Studies have found that USP22 deletion may lead to a significant reduction of MDSCs in the TME and promote the infiltration of T cells and NK cells while the expression of USP22 confers tumor resistance to immunotherapy (64)."
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"USP22 can regulate PD-L1 by deubiquitination and modulate the infiltration of T cells into malignancies 10."
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"99 The downregulation of USP22, according to a prior research, restricts the penetration of myeloid cells and enhances the infiltration of natural killer cells and T cells, hence improving tumor eradication in cancer immunotherapy."
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"We report that deletion of USP22 in pancreatic tumor cells reduced the infiltration of myeloid cells and promoted the infiltration of T cells and NK cells, leading to an improved response to combination immunotherapy."
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"Ablation of USP22 in liver tumor cells has been shown to increase tumor immunogenicity and promote infiltration of T cells into the resulting liver tumors."
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