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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

SCN5A activates LQT-3. 2 / 2

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"Among the numerous different genetic subtypes (all encoding a protein that is directly or indirectly involved in repolarization) of the syndrome, LQT-3 is caused by gain-of-function mutations in SCN5A."

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"2,3 Unlike LQT-1 and LQT-2, both loss-of-function potassium channelopathies, LQT-3 is caused by gain-of-function mutations in SCN5A, the cardiac sodium-channel gene."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...