IndraLab

Statements

USP22 inhibits STAT1. 4 / 4
| 4
reach
"Knockdown of USP22 can activate STAT1 signaling pathway, inhibit T-cell depletion, and promote the proliferation and activation of NK cells (75)."
35935969
reach
"USP22-deficient hIECs strongly 46 upregulate genes involved in IFN signaling and viral defense, including numerous IFN-47 stimulated genes (ISGs), with increased secretion of IFN-λ and enhanced STAT1 48 signaling, even in the absence of exogenous IFNs or viral infection."
| DOI
reach
"USP22-deficient hIECs strongly upregulate genes involved in IFN signaling and viral defense, including numerous IFN-stimulated genes (ISGs), with increased secretion of IFN-lambda and enhanced STAT1 signaling, even in the absence of exogenous IFNs or viral infection."
35933402
reach
"211 212 USP22 negatively regulates STAT1 signaling and IFN-λ1 expression 213 The expression of ISGs is typically induced upon activation of IFN signaling pathways 214 during pathogen invasion or autoinflammatory disease and serves to control 215 inflammation and other defensive mechanisms 9 ."
| DOI