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NEDD4 ubiquitinates KCNH2. 2 / 2

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"Nedd4, in association with caveolin-3 (Cav3), binds and ubiquitinates hERG channels, targeting them for degradation [XREF_BIBR]."

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"These results suggest that ubiquitylation of the hERG1 protein by Nedd4-2, and its subsequent down-regulation, could represent an important mechanism for modulation of the duration of the human cardiac action potential."

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IndraLab

Statements

NEDD4 ubiquitinates KCNH2. 2 / 2

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