IndraLab

Statements

NEDD4 ubiquitinates KCNH2. 2 / 2
1 | 1
reach
"Nedd4, in association with caveolin-3 (Cav3), binds and ubiquitinates hERG channels, targeting them for degradation [XREF_BIBR]."
24262338
signor
"We have previously shown that the E3 ubiquitin (Ub) ligase Nedd4-2 (neural precursor cell expressed developmentally down-regulated protein 4-2) targets the PY motif of hERG channels to initiate channel degradation. Although both immature and mature hERG channels contain the PY motif, Nedd4-2 selectively mediates the degradation of mature hERG channels."
26363003