IndraLab

Statements

TEA inhibits KCNQ1. 5 / 5
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"Based on the ability of external TEA to block the KCNQ1 channel similar to the KCNQ1 / minK channel, Kurokawa et al. [77] concluded that minK does not line the pore of the channel."
12623297
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"While external TEA was a weak inhibitor of both KvLQT1 and wild-type I Ks channels, channels formed with F54C-MinK and G55C-MinK were over five times more sensitive to external TEA; these mutations di[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10968999
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"Currents elicited in the first 120 ms of each test pulse showed no time delay and were assumed to be non-channel-dependent; these leak currents and their variances were subtracted.In whole-cell mode, [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10968999
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"On the other hand, the TEA block of KCNQ1 and KCNQ4 has a Hill slope of ~ 2 (Hadley et al., 2000), implying a different mechanism of block.The putative cognitive enhancer linopirdine and its more pote[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11448722
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"In addition, internal TEA was found to inhibit KCNQ1 in the presence or absence of KCNE1 expressed in Xenopus oocytes [XREF_BIBR]."
33322401