IndraLab
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"These results demonstrate that extended gefitinib exposure induces sustained UCHL3 downregulation and USP54 upregulation in gefitinib-resistant sublines, suggesting a potential interplay between these genes in NSCLC cells under prolonged drug exposure.Total RNA was extracted from PC9 cells treated with 1 μM gefitinib for 1, 6, and 24 h and analyzed by QuantSeq 3’ mRNA sequencing."