IndraLab

Statements

Phenethyl caffeate inhibits KCNH2. 4 / 5
| 3 1
reach
"CAPE dose-dependently decreased repolarization tail current of hERG (I hERG, tail; IC50, 10.6 +/-0.5 muM)."
23440458
sparser
"The CAPE inhibition of I hERG,tail was not attenuated in the pore-blocker site mutants of hERG (Y652A and F656A)."
23440458
reach
"Taken together, CAPE inhibits hERG channel by class 3 mechanism, i.e., modification of gating, not by blocking the pore."
23440458
reach
"Class 3 inhibition of hERG K+ channel by caffeic acid phenethyl ester (CAPE) and curcumin."
23440458