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OTUB1 inhibits ferroptosis. 18 / 18
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"Loss of OTUB1 inhibits bladder tumor growth and leads to ferroptosis."
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"The knockdown of OTUB1 triggered ferroptosis that depended on the expression of SLC7A11 [25, 26]."
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"CD44 and OTUB1 interact with SLC7A11 to enhance the protein stability and ferroptosis suppression [94]."
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"The interplay between ubiquitination and deubiquitination regulates intracellular protein catabolism and modulates ferroptosis.Studies have shown that the deubiquitinating enzyme OTUB1 inhibits ferroptosis by stabilizing SLC7A11 [67]."
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"Additionally, treatment with the ferroptosis inducer RSL3 markedly downregulated the expression of the myogenic genes MyoG and MyoD and decreased OTUB1 expression levels (Fig. 1I,J)."
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"Cancer cells overexpress deubiquitinase OUT deubiquitinase ubiquitin aldehyde binding 1 (OTUB1), which stabilizes cystine transporter SLC7A11, inhibits ferroptosis and promotes tumor growth (162)."
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"FTO or OTUB1 silencing increased ferroptosis, while their co-overexpression enhanced neuroprotective effects."
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"The authors showed OTUB1 inhibits ferroptosis in gastric cancer and promotes cell proliferation as well as migration and invasion."
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"The results show that OTUB1 knockdown in vitro significantly increased C2C12 ferroptosis and inhibited myogenesis."
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"96 Other SLC7A11/system Xc regulators include CD44 and OTUB1, which suppress ferroptosis by directly binding the SLC7A11 protein and increasing the stability of the latter.97 98 Beclin-1 (BECN1), a key autophagy regulator, on the other hand, inhibits system Xc by binding SLC7A11, and consequently promotes ferroptosis induced by system Xc inhibitors.99 GPX4 regulators."
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"Overall, TP53 plays dual roles in ferroptosis according to its target genes and partners.Exogenous scavenging of hydrogen sulfide (H 2 S) increases the stability of SLC7A11 by persulfidation of OTU de[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The direct interaction between ubiquitin hydrolase ovarian tumor domain protease domain, ubiquitin aldehyde binding protein 1 (OTUB1) and SLC7A11 stabilizes the SLC7A11 protein, and OTUB1 knockdown triggers SLC7A11 expression-dependent ferroptosis (13)."
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"Zhao et al. found that the ubiquitin hydrolase OTUB1 inhibits ferroptosis by stabilizing the SLC7A11 protein and promoting glioma cell stemness (67).2.4.4 Circular RNA."
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"Zhao et al. (32) indicated that OTUB1 inhibits ferroptosis and promotes stemness of glioma cells by stabilising the SLC7A11 protein."
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"Thirdly, OTUB1 represses ferroptosis in bladder cancer and gastric cancer (Liu et al., 2019; Li et al., 2023a)."
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"These results were also consistent with those of the SLC7A11 knockdown, validating that the knockdown of OTUB1 promoted ferroptosis and inhibited the proliferation in PASMCs via SLC7A11."
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"The stability of SLC7A11 was maintained by OTUB1, thereby inhibiting ferroptosis in pulmonary artery smooth muscle cells [24]."
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"For example, the deubiquitinase OTUB1 is abnormally upregulated in cancer cells and promotes tumor development to suppress ferroptosis by stabilizing the cystine transporter SLC7A11, which uptakes cystine and exports glutamate."
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