IndraLab

Statements

Formononetin inhibits NLRP3. 10 / 10
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"In this study, AG, mangiferin, and hederagenin inhibited the NF-κB signaling pathway, and THJ, TCT, and formononetin inhibited the NLRP3 signaling pathway to reduce the inflammatory response of DCM."
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"As shown in Fig. 3A, the abundance of NLRP3, ASC, caspase-1-p20, cleaved-IL-1β and cleaved-IL-18 in colonic tissue were increased in AP mice while formononetin treatment drastically reduced the activation of NLRP3 signaling pathway."
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"Formononetin inhibits the activation of NLRP3 inflammasome in colon and pancreas."
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"Meanwhile, formononetin reduced NLRP3 pathway protein levels in vivo and in vitro (NLRP3, ASC, IL-1β) (Wu et al., 2018)."
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"NLRP3 inflammasome signaling pathway was inhibited by Formononetin in dextran sulfate sodium induced acute colitis animal models [XREF_BIBR]."
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"All these data above suggested that formononetin reduced AP-induced intestinal inflammation by inhibiting the activation of NLRP3 inflammatory pathways."
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"Formononetin rebalances microglial M1/M2 polarization, inhibits NLRP3 inflammasome and enhances autophagy in prefrontal cortex."
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"In vitro and in vivo, formononetin significantly inhibited toll-like receptor 4 (TLR4) and estrogen receptor (ESR1)/Nod-like receptor family pyrin domain-containing protein 3 (NLRP3)/Caspase-1 signaling."
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"Formononetin Inhibited NLRP3 Pathway in Mice Colonic Epithelial Cells."
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"In this study, by using immunohistochemical staining, we firstly detected that the expression of NLRP3 in colonic tissue was elevated in DSS induced colitis and formononetin reduced the activation of NLRP3 pathway (XREF_FIG)."
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