IndraLab

Statements

USP9X activates SOX2. 7 / 7
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"Overexpression of USP9x resulted in SOX2 elevation in a dose-dependent manner ( Fig. 4 B), and significantly prolonged the half-life of SOX2 ( Fig. 4 C)."
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"MG132 treatment reversed the reduction of SOX2 by Usp9x KD, indicating that ubiquitin proteasome pathway plays a role in controlling SOX2 levels (XREF_FIG)."
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"Previous studies have identified that USP9X upregulates SOX2 at both mRNA and protein levels."
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"Indeed, USP9x can interact with and increase the stability of SOX2 through regulating the K48-linked ubiquitination of SOX2."
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"Exogenous overexpression of Usp9x in SK-Mel29 cells lead to upregulation of SOX2 (XREF_FIG) and as expected, increased 3D tumor growth (XREF_FIG)."
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"We found that USP9x remarkably upregulated SOX2 protein level ( Fig. 4 A)."
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"Usp9x knockdown , as well as inhibition with DUB inhibitor , G9 , blocked SOX2 expression , suppressed in vitro colony growth , and induced apoptosis of BRAF-mutant melanoma cells ."
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