IndraLab

Statements

OTUB1 inhibits MAPT. 2 / 2
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"Endogenous Otub1 depletion significantly inhibited Tau aggregation, with the level of inhibition correlating with the level of knockdown efficiency, while use of a control siRNA did not affect levels of Otub1 nor aggregation efficiency."
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"Tau is deubiquitinated from the K48-linked polyubiquitination chain by OTUB1, thereby indicating that OTUB1 prevents the decomposition of Tau by removing the polyubiquitin chain of K48 on Tau in mouse[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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