IndraLab

Statements

NS3623 activates KCNH2. 6 / 6
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"In contrast, application of NS3623 to the mutant F656M increased HERG1 current to a larger extent than what was observed with wild-type HERG1 channels."
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"In contrast, hERG1 channel activation by NS1643 and NS3623 preserves the wild-type function making the channels primarily active in the repolarising phase of the action potential."
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"3.7 Effect of KChIP2 and DPP6 in the NS3623 mediated I hERG activation."
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"NS3623 enhances hERG current magnitude by reducing channel inactivation with little or no effect on the rate of deactivation [13] ."
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"The results show that I hERG is quickly, and reversibly, activated by NS3623."
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"RPR260243 induces two distinct changes in hERG gating: a slowing of deactivation and a positive shift in the voltage-dependence of inactivation [9,15] , while NS1643 and NS3623 enhance hERG current ma[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19426677