IndraLab

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OTUB1 inhibits Neoplasms. 7 / 7
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"Inducible deletion of Otub1 in adult mice greatly promoted tumor rejection, associated with increased tumor-infiltration with various immune cells, including CD8 T cells, NK cells, as well as CD4 T cells and cDC1 cells."
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"These data suggested that OTUB1 inhibited anti-tumor macrophage M1 polarization.Previous results demonstrated the tumor promoter of OTUB1 in vitro , and we further investigate the influence of OTUB1 o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Inducible OTUB1 deletion of adult mice promotes tumor rejection, which is related to the increased tumor infiltration of NK cells, CD8 + T cells, CD4 + T cells and cDC cells."
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"4.4.1 OTUB1 suppresses tumor immunity."
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"As a result, silencing OTUB1 increases tumor sensitivity to T-cell mediated cytotoxicity."
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"In addition, OTUB1 inhibits tumor immune surveillance by another mechanism."
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"To validate the potential key role of RACK1 in OTUB1-mediated tumor suppression, we performed the exogenous Co-IP assay first."
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