IndraLab

Statements


SMAD2 bound to SMAD3 and SMAD4 activates SMAD4. 1 / 1
1 |

"from Figure 1 - Fig 1. The transforming growth factor beta (TGF-b) signaling pathway. TGF-b binds type II TGF-b receptor (TbRII), directly or through TbRIII, inducing association of TbRII with TbRI. TbRII then phosphorylates and activates TbRI, which then phosphorylates Smad2 or Smad3. Phosphorylated Smad2 or Smad3 associates with Smad4 and they translocate into the nucleus, where they activate transcription of target genes. Smad7 inhibits TGF-b signaling by preventing the activation of Smad2 or Smad3 by TbRI."