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UCHL1 increases the amount of APP. 2 / 2

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"Inhibition of UCHL1 activity significantly increased BACE1 protein expression and increased concentrations of amyloid β, whereas overexpression of UCHL1 decreased amyloid β levels and delayed AD progression (Zhang et al., 2014; Zhang et al., 2012)."

36681249

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reach

"Depletion of UCHL1 increases the levels of BACE1, C99, and Abeta in the Uchl1-null gad mice."

28018215

INDRA sources:

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IndraLab

Statements

UCHL1 increases the amount of APP. 2 / 2

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