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Statements


PDGF activates COPS6. 3 / 3
| 3

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"These results suggest that PDGFR mediates PDGF-induced up-regulation of CSN6 in PASMCs.Next, we examined whether activation of PDGFR mediates down-regulation of β-TrCP in PDGF-stimulated PASMCs."

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"Fig. 2 B shows that PDGF increased the protein level of CSN6 in a time-dependent manner, and peak time for 10 ng/ml PDGF up-regulation of CSN6 was 10 min, suggesting that CSN6 is up-regulated in PASMC[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"These results indicate that PDGFR mediate PI3K/Akt signaling pathway activation in PASMCs treated with PDGF.To examine whether activation of PDGFR mediates PDGF-induced up-regulation of CSN6 in PASMCs[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"