IndraLab

Statements

USP8 inhibits regulation of cell cycle. 4 / 4
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"USP8 depletion stimulated cell cycle arrest and apoptosis.ER-positive BC is characterized by slow disease progression and relatively good prognosis, while 30% of patients suffer from metastases or endocrine resistance due to clinical heterogeneity [24]."
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"USP8 knockdown markedly induced apoptosis and cell cycle arrest (G0/G1)."
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"USP8 depletion also caused cell cycle arrest at the G0/G1 phase in two different BC cell lines, which is in line with previous studies [39]."
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"Knockdown of EGFR or USP8 suppressed the TCHP-AurA pathway, induced unscheduled ciliogenesis, and caused cell cycle arrest of RPE1 cells, even in the presence of serum."
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