IndraLab

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Sodium(1+) inhibits NLRP3. 11 / 11
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"Sodium Butyrate and beta-Hydroxybutyric Acid Topical Treatment Inhibits Activation of NLRP3 Inflammasome in Alkali Injured Corneas."
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"It also ameliorates dextran sulfate sodium induced colitis in caspase-1 -/- mice by inhibiting the activation of NLRP3 inflammasomes and the subsequent secretion of IL-1beta."
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"Furthermore, excess extracellular Cl or K , but not sodium, inhibited the decline in intracellular K levels (Supplementary Fig. 17), and blocked NLRP3 activation and IL-1β generation (Supplementary Figs."
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"SH (sodium houttuyfonate) inhibited the NLRP3/GSDMD pathway and improved hippocampal neuronal pyroptosis and spatial learning memory deficits in Aβ1-42-induced AD mice (Zhao et al., 2021)."
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"Sodium butyrate (NaB) inhibits the activation of NLRP3 inflammasome and cytokine expression in 3T3-L1 adipocytes pretreated with TNF-alpha to mimic the inflammatory state [XREF_BIBR]."
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"[Sodium Ferulate Attenuates Oxidative Stressvia Suppressing NALP3 Inflammasome and ERK Signal Pathway]."
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"Dimethyl fumarate (DMF) and 3-(2-oxo-2-phenylethylidene)-2,3,6,7-tetrahydro-1H-pyrazino-[2,1-a]isoquinolin-4(11bH)-one (compound 1), the Nrf2 activators, were found to ameliorate dextran sulfate sodium (DSS)-induced colitis (an animal model mimicking human IBD) via activating Nrf2 and inhibiting NLRP3 inflammasome [121,122]."
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"For example, Wang et al. reported that sodium butyrate treatment can efficiently inhibit Nlrp3 inflammasome activation and thereby inhibits obesity induced inflammation, indicating that NaB might be a potential anti-inflammatory agent for obesity in db/db mice XREF_BIBR."
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"Thus, our finding suggested that sodium butyrate relieved LPS induced inflammatory responses in bovine macrophage by inhibiting the canonical NF-kappaB, NLRP3 signaling pathway, and histone decetylation, which might be helpful to prevent cow mastitis."
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"Sodium butyrate has a similar chemical structure to HBA and also has been reported to inhibit the NLRP3 pathway [XREF_BIBR]."
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"Conclusions : Sodium butyrate can inhibit the activation of NLRP3 inflammasome and decrease the production of IL-1beta and IL-18 in intestinal mucosa of severe scald mice, which protects the intestinal barrier function by alleviating the alteration of tight junction protein expression and localization."
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