IndraLab

Statements



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"Here, we observed that inhibition of CHAC1 mRNA expression by siRNA promoted IL-8 and CCL2 expression and PGE2 secretion, suggesting that CHAC1 prevents excessive inflammatory responses dependent on the NF-κB p65 pathway."

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"DNJ increased the levels of prostaglandin E2, COX-1, COX2, and reduced the levels of and NF-kappaB p65 (P < 0.05)."

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"Interestingly, PGE2 or di-butyryl (Bt2) cAMP abolished the binding of NF-kappa B (p50 and p65) heterodimer to the kappa B sequence in cells stimulated with anti-CD3 mAb but not with PMA and A23187."